Julia Lewis provided funding for Lewis Hall’s construction in 1965, dedicating it in honor of her husband, Frank Lewis, a Chicago philanthropist. Lewis Hall served as a residence for Sisters pursuing graduate degrees before the University became co-ed in 1972. Notable past residents include Anne Thompson '79 (NBC news reporter).

Every Spring the women of Lewis celebrate with one of Notre Dame’s most distinct dances, the “Lewis Crush.” In this dance, guests are invited anonymously through an ad in the Notre Dame student newspaper The Observer. Guests find out who invited them officially at the Lewis BBQ held the night before the dance.